Opportunity Information: Apply for RFA DA 21 006
The BRAIN Initiative: Tools for Germline Gene Editing in Marmosets (U01 - Clinical Trial Not Allowed) funding opportunity (RFA-DA-21-006) is a National Institutes of Health (NIH) cooperative agreement designed to build and improve the practical research infrastructure needed to carry out transgenic and gene-editing work in the common marmoset (Callithrix jacchus). The core aim is not simply to fund individual biology experiments, but to develop the tools, technologies, and supporting workflows that make marmoset germline and somatic genetic manipulation more scientifically rigorous, ethically grounded, efficient, and cost-effective. The broader motivation is to enable research that requires targeted genetic perturbations in a non-human primate model, specifically to advance BRAIN Initiative goals related to understanding how the brain works in both health and disease.
A central emphasis of the announcement is infrastructure: technologies and methods that reliably support germline gene editing (heritable changes passed to offspring) and somatic gene editing (non-heritable edits in specific tissues or cell populations). In practice, this type of program typically supports enabling capabilities such as improved delivery approaches, validated editing pipelines, quality control and genotyping strategies, colony and breeding support systems, standardized operating procedures, and approaches that reduce variability while improving reproducibility. The FOA explicitly frames these developments as necessary for answering high-value neuroscience questions that cannot be addressed as well in simpler model organisms when primate-specific brain features, circuitry, or behavior are central to the scientific problem.
Because the award mechanism is a U01 cooperative agreement, recipients should expect substantial scientific and programmatic involvement from NIH staff compared with a standard research project grant. Cooperative agreements are commonly used when the agency anticipates active coordination, milestone-driven progress, shared resources, or community-facing deliverables. In this case, the deliverables are implied to be tools and technologies that enable a wider ecosystem of marmoset gene-editing research aligned with BRAIN objectives, rather than one-off, closed efforts that are difficult to replicate elsewhere. The listing also specifies "Clinical Trial Not Allowed," meaning the supported work must remain preclinical and should not be proposed as a human clinical trial.
Eligibility is broad and includes many organization types across government, academia, nonprofit, and industry. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (in both cases, other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The opportunity also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This wide eligibility reflects the reality that building reliable marmoset gene-editing capacity can require coordinated expertise spanning primate biology and husbandry, genome engineering, neuroscience, ethics and compliance, data and quality systems, and scalable operations.
Administrative details in the source data indicate the sponsoring agency is NIH, the opportunity category is discretionary, and the activity categories include education, environment, health, and income security and social services, consistent with NIH listings that span multiple CFDA/assistance numbers. The original closing date listed is October 14, 2022, and the FOA creation date is July 17, 2020. The award ceiling and expected number of awards are not specified in the provided excerpt, which typically means applicants would need to consult the full FOA text for budget expectations, project period limits, and whether NIH set specific caps or anticipated award counts.
Overall, this FOA is best understood as a capacity-building and technology-development program focused on making marmoset germline and somatic gene editing more dependable and broadly usable for neuroscience. By strengthening the underlying toolchain and infrastructure, the program aims to unlock experiments that depend on primate-relevant neurobiology and behavior, thereby supporting the BRAIN Initiative mission to map, measure, and understand brain function and dysfunction with model systems that better reflect key aspects of the human brain.Apply for RFA DA 21 006
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Tools for Germline Gene Editing in Marmosets (U01 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2020-07-17.
- Applicants must submit their applications by 2022-10-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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