Opportunity Information: Apply for PA 22 178
The PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer (STTR) Grant Applications is a NIH funding opportunity (PA 22-178) designed to support early-stage research and development projects led by eligible U.S. small businesses working in formal partnership with a nonprofit research institution. It uses the NIH Parent STTR mechanisms R41 (Phase I) and R42 (Phase II) and is meant to help small companies translate promising scientific ideas into tangible products, tools, or technologies that align with the research and development missions of participating NIH awarding components. The solicitation is part of the broader NIH/CDC/FDA SBIR/STTR ecosystem, and applicants are expected to propose projects that fit within the specific program descriptions and research topics listed under the PHS 2022-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA.
A key point is that this is a "clinical trial not allowed" parent announcement. In practical terms, proposals must be structured so they do not include NIH-defined clinical trials (for example, prospective assignment of human participants to interventions to evaluate effects on health-related biomedical or behavioral outcomes). Projects can still be highly health-focused and may involve preclinical development, prototype building, assay development, software or device engineering, validation testing, and other non-clinical-trial research activities that advance a technology toward commercialization. If a company intends to run a clinical trial, it would need to seek a different FOA that explicitly allows clinical trials rather than using this parent STTR route.
Eligibility is limited to U.S. small businesses. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. That said, the announcement notes that "foreign components," as defined in the NIH Grants Policy Statement, may be allowed in some cases, which typically means discrete elements of work may be performed outside the U.S. only when strongly justified and consistent with NIH policy. The agency listed is the National Institutes of Health, and the instrument type is a discretionary grant. The activity categories span multiple public-purpose areas (including health, education, environment, food and nutrition, and social services), reflecting the broad range of NIH-related R and D topics that may be supported through participating institutes and centers.
From a funding and administrative standpoint, the opportunity is tied to multiple CFDA (assistance listing) numbers, indicating participation across many NIH institutes and programs (and potentially related HHS components reflected in the topic document). The source data shows an award ceiling of $275,766, which signals a per-award cap as represented in the posting (actual budgets and allowable costs are typically governed by the STTR program rules, the specific phase, NIH policy, and any topic-specific guidance). The original closing date in the provided record is 2023-04-05, and the FOA record creation date is 2022-06-02. Because omnibus SBIR/STTR solicitations often operate with standard due dates and cycles, applicants normally need to pay close attention to the applicable submission window(s), standard NIH due dates for SBIR/STTR, and any updates or reissuances connected to the parent announcement.
Overall, this FOA functions as a broad entry point for U.S. small businesses that want to pursue NIH-aligned, commercialization-oriented R and D through the STTR model, while staying clearly outside the boundaries of clinical trial work. The best fit applicants are companies with a strong technical plan, a well-defined commercialization path, and a capable nonprofit research partner, proposing a project that maps cleanly to one of the identified NIH/CDC/FDA topic areas referenced by the PHS 2022-2 topic document.Apply for PA 22 178
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.350, 93.351, 93.361, 93.394, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.867, 93.879.
- This funding opportunity was created on 2022-06-02.
- Applicants must submit their applications by 2023-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,766.00 in funding.
- Eligible applicants include: Small businesses.
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| Funding Opportunity |
|---|
| PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 22 176 Funding Number: PA 22 176 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| Maternal Health Research Centers of Excellence Data Innovation and Coordinating Hub/Resource Center (U24 Clinical Trial Not Allowed) Apply for RFA HD 23 036 Funding Number: RFA HD 23 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence Implementation Science Hub/Resource Center (U24 Clinical Trial Optional) Apply for RFA HD 23 037 Funding Number: RFA HD 23 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence (U54 Clinical Trial Optional) Apply for RFA HD 23 035 Funding Number: RFA HD 23 035 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $17,500,000 |
| Open Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 017 Funding Number: RFA OD 22 017 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Laboratory Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 016 Funding Number: RFA OD 22 016 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Coordinating Center (U2C) (Clinical Trial Not Allowed) Apply for RFA OD 22 021 Funding Number: RFA OD 22 021 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 019 Funding Number: RFA OD 22 019 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Data Analysis Center (U24) Clinical Trial Not Allowed Apply for RFA OD 22 022 Funding Number: RFA OD 22 022 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy and Pediatric Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 018 Funding Number: RFA OD 22 018 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Measurement Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 020 Funding Number: RFA OD 22 020 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 23 048 Funding Number: PA 23 048 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional) Apply for PAR 23 112 Funding Number: PAR 23 112 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
| Emergency Award: Novel Insights through Cross-Site Analyses of Existing RADx-UP Data (R21 Clinical Trial Not Allowed) Apply for RFA OD 23 050 Funding Number: RFA OD 23 050 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,000 |
| Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional) Apply for PAR 23 166 Funding Number: PAR 23 166 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Collaborative Partnership to Advance Global Health Research (U01 Clinical Trial Not Allowed) Apply for PAR 23 203 Funding Number: PAR 23 203 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $2,360,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 23 260 Funding Number: PA 23 260 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 23 272 Funding Number: PA 23 272 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 23 262 Funding Number: PA 23 262 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 23 261 Funding Number: PA 23 261 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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