Opportunity Information: Apply for PAR 27 067
The NIH funding opportunity PAR-27-067 is a limited-competition Notice of Funding Opportunity (NOFO) for the Instrumentation Grant Program for Resource-Limited Institutions (S10). Its core purpose is to help eligible, resource-limited institutions purchase a single, modern, state-of-the-art scientific instrument that meaningfully strengthens both their research capacity and their educational mission. The program is aimed at improving access to shared, high-end instrumentation that an institution might not otherwise be able to afford, with the expectation that the instrument will be used to support a broader community of users rather than serving only one lab.
The types of activities supported under this NOFO center on instrumentation that enables biomedical research and related education across a wide spectrum of fields. NIH indicates that requested instruments may support basic research, translational research, and biomedically related behavioral or clinical research and education. In practical terms, that means the instrument should be justified by how it will advance the scientific work and training happening at the institution, such as enhancing data quality, expanding methodological capabilities, improving throughput or sensitivity, enabling new experimental approaches, or providing students and trainees hands-on access to technologies commonly used in modern biomedical science.
This is an S10 mechanism and is explicitly marked “Clinical Trial Not Allowed,” which means the grant is not intended to support the conduct of clinical trials. The focus is on purchasing equipment rather than running clinical studies, and applicants should frame the proposed instrument’s use around research and educational objectives that fit within NIH’s non-clinical-trial boundaries for this opportunity.
A key feature of this NOFO is that it is a limited competition. Instead of being open to all applicants at any time, the program will invite applications only from organizations that meet specific eligibility requirements described in Section III of the NOFO. NIH will use its standard peer-review process to evaluate submitted applications, and only those judged meritorious through peer review will be considered for funding. In other words, even if an organization is eligible to apply, an award is still contingent on the application’s scientific and programmatic strength as assessed by NIH review.
The applicant eligibility categories listed in the opportunity reflect a wide range of domestic U.S. organizations that can potentially participate, subject to the additional “resource-limited” and invitation-based constraints described in the NOFO. Eligible applicant types include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other applicant types NIH may allow under the solicitation’s rules. Despite this broad list, the “limited competition” and “resource-limited institution” focus is the gatekeeper, so the detailed eligibility language in the NOFO is critical.
Foreign involvement restrictions are strict. Non-U.S. entities (foreign organizations) are not eligible to apply. Non-U.S. components of U.S. organizations are also not eligible. In addition, foreign components, as defined by the NIH Grants Policy Statement, are not allowed. This effectively means the project, instrument location, and the supported activities must remain within allowable domestic boundaries, without foreign components embedded in the project structure.
From a funding standpoint, the opportunity is a discretionary NIH grant within the health funding activity category, associated with multiple CFDA numbers (93.121, 93.172, 93.173, 93.242, 93.286, 93.351, 93.846, 93.853, 93.859, 93.866, 93.867), reflecting that multiple NIH institutes and centers may participate in supporting awards under the broader instrumentation and shared resources landscape. The award ceiling is listed as $250,000, indicating the maximum amount that can be requested or awarded under the terms of this announcement. The “ExpectedAwards” field is not specified in the provided data, so the number of awards is not stated here and may vary by NIH priorities and available funds over time.
Timing details in the source data show an original closing date of 2029-01-26 and a creation date of 2026-05-27, indicating a multi-year window in which this NOFO exists, with specific application due dates and/or invitation cycles governed by the limited-competition structure and the schedule in the full announcement. Because limited competitions often involve institutional nomination or an NIH invitation process, the practical next step for an interested organization is to confirm it meets the “resource-limited” definition and then follow the instructions in Section III and any related NIH guidance on how and when invitations or submissions occur.
In plain terms, this grant is designed to help a qualifying U.S. institution acquire one significant piece of scientific equipment that can be shared and leveraged to raise the overall level of biomedical research and education at that institution. Success depends heavily on demonstrating broad institutional benefit, strong justification for the selected instrument, alignment with NIH’s non-clinical-trial scope, compliance with strict domestic-only requirements, and competitiveness under NIH peer review within an invitation-based, limited applicant pool.Apply for PAR 27 067
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.173, 93.242, 93.286, 93.351, 93.846, 93.853, 93.859, 93.866, 93.867.
- This funding opportunity was created on 2026-05-27.
- Applicants must submit their applications by 2029-01-26.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PAR-27-067 Instrumentation Grant Program for Resource-Limited Institutions (S10)
What is PAR-27-067?
PAR-27-067 is an NIH Notice of Funding Opportunity (NOFO) for the Instrumentation Grant Program for Resource-Limited Institutions (S10). It is a limited-competition funding opportunity focused on helping eligible, resource-limited institutions purchase a single, modern, state-of-the-art scientific instrument that strengthens research capacity and supports the institution's educational mission.
What is the main goal of this grant program?
The core goal is to improve access to shared, high-end scientific instrumentation that a resource-limited institution might not otherwise be able to afford. NIH expects the instrument to benefit a broader community of users and to meaningfully enhance both biomedical research and related education at the institution.
What does "S10" mean in this context?
S10 refers to an NIH instrumentation grant mechanism. In this opportunity, the S10 mechanism is used to support the purchase of scientific equipment (instrumentation) rather than to fund a traditional research project.
Is this opportunity open to all applicants?
No. This is a limited-competition NOFO. Applications are expected only from organizations that meet the specific eligibility requirements described in Section III of the NOFO and are invited under the program's limited-competition structure.
What does "limited competition" mean for applicants?
Limited competition means the opportunity is not broadly open to all applicants at any time. Instead, NIH will invite applications only from organizations that meet defined eligibility criteria. Even if an organization is eligible, funding is not guaranteed because applications must still be competitive and score well in NIH peer review.
What types of institutions are generally listed as eligible applicant organizations?
The eligibility categories listed include many U.S. domestic organization types, such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other applicant types NIH may allow under the solicitation's rules. However, the "resource-limited institution" requirement and invitation-based process are the key constraints.
What does "resource-limited institution" mean in this program?
This opportunity targets "resource-limited" institutions, and the specific definition and qualifying criteria are described in Section III of the NOFO. Meeting the general applicant type list alone is not enough; the institution must satisfy the resource-limited criteria and any related requirements tied to the limited-competition process.
What is NIH funding applicants expected to purchase?
The program is designed to fund the purchase of a single, modern, state-of-the-art scientific instrument. The instrument should be justified based on how it will meaningfully strengthen the institution's research capabilities and educational mission, and how it will be shared by a broader community of users.
Does the grant support buying multiple instruments?
Based on the provided information, the intent is to purchase a single instrument. Applicants should plan around selecting one piece of major equipment and building a strong justification for why that specific instrument best advances research and education at the institution.
Does the instrument need to be shared across the institution?
Yes. A key expectation is that the instrument will support a broader community of users rather than serving only one laboratory. The application should emphasize shared access and broad institutional benefit.
What kinds of research and education can the instrument support?
NIH indicates the instrument may support basic research, translational research, and biomedically related behavioral or clinical research and education. The instrument should be justified by how it advances scientific work and training at the institution, such as improving data quality, expanding methodological capabilities, improving throughput or sensitivity, enabling new experimental approaches, and providing hands-on access for students and trainees to modern biomedical technologies.
Are clinical trials allowed under this NOFO?
No. The opportunity is explicitly marked "Clinical Trial Not Allowed." This means the grant is not intended to support the conduct of clinical trials. Applicants should frame instrument use around research and educational objectives that fit within NIH's non-clinical-trial boundaries for this program.
If clinical trials are not allowed, can the instrument still support clinical or behavioral research?
The provided information indicates the instrument may support biomedically related behavioral or clinical research and education, but the award is not intended to support the conduct of clinical trials. Applicants should keep proposed activities within the "Clinical Trial Not Allowed" scope.
How will NIH decide which applications receive awards?
NIH will use its standard peer-review process to evaluate submitted applications. Only applications judged meritorious through peer review will be considered for funding, and final awards are contingent on both review outcomes and NIH programmatic considerations.
What is the maximum award amount under PAR-27-067?
The award ceiling listed is $250,000, which indicates the maximum amount that can be requested or awarded under the terms of this announcement.
How many awards will NIH make?
The number of expected awards is not specified in the provided information. The actual number may vary depending on NIH priorities and available funds over time.
Are foreign organizations eligible to apply?
No. Non-U.S. entities (foreign organizations) are not eligible to apply under this opportunity.
Can a U.S. organization apply if it has a non-U.S. component involved?
No. Non-U.S. components of U.S. organizations are not eligible. In addition, foreign components (as defined by the NIH Grants Policy Statement) are not allowed, which means the project structure and supported activities must remain within allowable domestic boundaries without foreign components embedded in the project.
Does this NOFO allow foreign components as part of the project?
No. Foreign components are not allowed under this opportunity, according to the provided information.
What is the funding category for this opportunity?
The opportunity is described as a discretionary NIH grant within the health funding activity category.
Which CFDA numbers are associated with this NOFO?
The opportunity is associated with multiple CFDA numbers: 93.121, 93.172, 93.173, 93.242, 93.286, 93.351, 93.846, 93.853, 93.859, 93.866, and 93.867. This reflects that multiple NIH institutes and centers may participate in supporting awards under the broader instrumentation and shared resources landscape.
What is the closing date listed for this opportunity?
The source data shows an original closing date of 2029-01-26, indicating a multi-year window in which this NOFO exists.
Does the closing date mean applications can be submitted at any time until 2029?
Not necessarily. The opportunity is a limited competition with invitations and specific schedules governed by the full announcement. Practical submission timing is expected to be controlled by the limited-competition structure and the application schedule described in the NOFO.
What is the creation date listed for this opportunity?
The source data lists a creation date of 2026-05-27.
What is the most important thing an applicant should demonstrate in the application?
Based on the provided description, competitiveness will depend heavily on demonstrating broad institutional benefit, strong justification for the selected single instrument, alignment with NIH's non-clinical-trial scope, compliance with strict domestic-only requirements (no foreign organizations or foreign components), and overall scientific and programmatic strength under NIH peer review.
What should an interested organization do first?
An interested organization should confirm it meets the "resource-limited" definition and other eligibility requirements described in Section III of the NOFO, and then follow NIH instructions on how and when invitations and submissions occur under the limited-competition structure.
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