Opportunity Information: Apply for RFA DK 15 506
This grant opportunity, RFA-DK-15-506, is a limited-competition NIH cooperative agreement (UC4) focused on extending and leveraging the existing Environmental Determinants of Diabetes in the Young (TEDDY) study to better understand how epigenetic changes and infectious exposures influence the development of islet autoimmunity and type 1 diabetes. TEDDY is a long-running epidemiological cohort that has tracked children at increased genetic risk for type 1 diabetes, collecting extensive clinical information along with biological samples over time. The central idea behind this FOA is that TEDDY is uniquely positioned to answer questions about how early-life exposures and biological regulation interact over childhood to shape autoimmune risk, but doing so requires continued, coordinated follow-up and high-quality management of data and biospecimens.
The funding is specifically intended for the TEDDY Data Coordinating Center (DCC) that has been involved since the beginning of the consortium, meaning the competition is restricted to an incumbent or similarly situated center with deep, continuous involvement in TEDDY study design, operational coordination, and the acquisition and management of TEDDY data and biosamples. The DCC is expected to provide the research infrastructure and coordination needed to continue following TEDDY participants and to support TEDDY collaborators who want to conduct additional studies using TEDDY samples, particularly studies that measure and analyze epigenetic marks (for example, DNA methylation or other regulatory signatures) and infectious exposures (such as evidence of viral or other pathogen encounters). In practice, this emphasizes maintaining the cohort, preserving the integrity of longitudinal data, ensuring biosample availability and quality, and enabling rigorous downstream analyses by the broader research team.
Because the award mechanism is a cooperative agreement, the project is structured around substantial NIH program involvement rather than functioning like a standard investigator-initiated grant. That typically means close coordination with NIH on milestones, governance, data sharing expectations, and consortium-wide priorities, reflecting the high-impact, infrastructure-heavy nature of supporting a large longitudinal cohort and its associated repository of data and specimens.
From an administrative and funding perspective, the opportunity sits within NIH and is categorized under health-related funding activities, with CFDA numbers listed as 93.847, 93.855, and 93.856. The FOA lists an award ceiling of $22,000,000 and anticipates a single award, reinforcing that this is meant to sustain a single coordinating hub rather than fund multiple independent projects. The original closing date was March 3, 2016, and the announcement was created October 2, 2015. Eligible applicant organizations include public and state-controlled institutions of higher education, private institutions of higher education, and other entities, and it explicitly notes that non-U.S. (foreign) organizations may be eligible as well, which fits TEDDY's international, multi-site character.
Overall, the opportunity is best understood as continued support for the TEDDY coordinating infrastructure so the cohort can keep being followed and so the field can capitalize on TEDDY's uniquely rich longitudinal samples and exposure data to investigate how infections and epigenetic regulation contribute to the onset and progression of autoimmunity and type 1 diabetes. The deliverable is not just new scientific findings, but the sustained ability of the TEDDY consortium to generate them by maintaining a well-run, high-quality data and biosample ecosystem.Apply for RFA DK 15 506
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition: Understanding How Epigenetics and Infections Impact Autoimmunity and Diabetes in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847, 93.855, 93.856.
- This funding opportunity was created on 2015-10-02.
- Applicants must submit their applications by 2016-03-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $22,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education, Private institutions of higher education, Others.
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