Opportunity Information: Apply for RFA CA 17 020
This grant opportunity, titled "Revision Applications to National Cancer Institute (NCI)-supported U01 Awards to Include Research on the NCI's Provocative Questions (U01)" (Funding Opportunity Number RFA-CA-17-020), is a National Institutes of Health program that supports add-on work to projects that are already funded under an active NCI U01 cooperative agreement. The key point is that this is not a brand-new standalone award mechanism for new U01 projects; it is specifically for revision applications (often understood as competitive supplements or scope expansions) submitted by investigators who already hold an active NCI-supported U01 research project award and want to expand that existing project with new, additional aims.
The scientific focus is tightly tied to the NCI's Provocative Questions (PQs), a set of high-priority cancer research questions designed to push the field toward important, stubborn, or understudied problems. Under this FOA, revision applications are expected to propose research that aligns with one of 12 PQs that were published for new applications under two related announcements: RFA-CA-17-017 (R01) and RFA-CA-17-018 (R21). In practice, that means an applicant must pick a PQ from that set and clearly show how the proposed new work advances, tests, or applies research related to that question within the context of their ongoing U01 project.
The FOA emphasizes several types of contributions. It encourages research that directly addresses a Provocative Question, but it also welcomes work that helps validate outcomes emerging from PQ-related research, as well as efforts aimed at adopting, disseminating, or translating PQ-driven findings in ways that can meaningfully affect cancer research and clinical care. That framing signals that the NCI is not only interested in generating new discoveries aligned with the PQs, but also in strengthening the evidence base around PQ findings and helping ensure that results move into broader use when appropriate.
From a project-structure standpoint, the proposed studies must be framed as additional specific aims that expand the scope of the parent U01 award. In other words, the revision application should be written as a coherent extension of the currently funded U01, not as a separate, unrelated project. The new aims should fit logically with the original goals, resources, and collaborative structure of the U01, while still being substantial enough to count as a meaningful scope expansion connected to a Provocative Question.
On the administrative side, this is a discretionary funding opportunity using the cooperative agreement mechanism, which means NCI program staff are typically expected to have substantial involvement during conduct of the project compared with a standard grant. The activity category is listed under education and health, and the CFDA numbers associated with the opportunity are 93.393, 93.394, 93.395, 93.396, and 93.399, reflecting the NCI-related federal assistance catalog entries that may apply to funded awards.
Eligibility is broad in terms of institution types, but it is constrained by the requirement that applicants must already have an active NCI U01 award to revise. Within that context, the FOA lists many eligible applicant categories, including state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education where specified); for-profit organizations other than small businesses; and small businesses. It also explicitly highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations, indicating that a wide range of organizational settings can participate so long as the revision is tied to an active NCI U01 award.
Key dates and funding parameters included in the source data show that the FOA was created on 2017-03-13 and had an original closing date of 2018-01-23. The award ceiling is listed as $150,000, which suggests the revision funding is intended to support a bounded set of additional activities rather than a full-scale new project budget. The number of expected awards is not specified in the provided data, implying the total number could depend on application volume, availability of funds, and program priorities at the time of review.
In practical terms, the opportunity is aimed at leveraging the infrastructure, teams, and momentum of ongoing NCI U01 projects to rapidly address one of the designated Provocative Questions through new, targeted aims. The NCI's intent is to accelerate progress on these strategically chosen research questions and, where relevant, strengthen the pathway from PQ-driven research insights to broader validation, implementation, and impact on cancer research and patient care.Apply for RFA CA 17 020
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to National Cancer Institute (NCI)-supported U01 Awards to Include Research on the NCI's Provocative Questions (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on 2017-03-13.
- Applicants must submit their applications by 2018-01-23. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (RFA CA 17 020) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revision Applications to National Cancer Institute (NCI)-supported P01 Awards to Include Research on the NCI's Provocative Questions (P01) Apply for RFA CA 17 021 Funding Number: RFA CA 17 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to National Cancer Institute (NCI)-supported P50 Awards to Include Research on the NCI's Provocative Questions (P50) Apply for RFA CA 17 022 Funding Number: RFA CA 17 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to NCI-supported R01 Awards to Include Research on the NCI's Provocative Questions (R01) Apply for RFA CA 17 019 Funding Number: RFA CA 17 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Supplements for Validating the Use of Automated Sources of Residential Histories in Cancer Epidemiology Cohorts (Admin Supp) Apply for PA 17 222 Funding Number: PA 17 222 Agency: National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Research Supplements to Promote Sharing Data in Cancer Epidemiology Studies (Admin Supp) Apply for PA 17 224 Funding Number: PA 17 224 Agency: National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Supplement Opportunity to Support Population-Based Research Studies of Rare Cancers (Admin Supp) Apply for PA 17 223 Funding Number: PA 17 223 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Advancing the Science of Geriatric Palliative Care (R01) Apply for PA 17 225 Funding Number: PA 17 225 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advancing the Science of Geriatric Palliative Care (R21) Apply for PA 17 226 Funding Number: PA 17 226 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01) Apply for PAR 17 233 Funding Number: PAR 17 233 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Mechanisms and Consequences of Sleep Disparities in the U.S. (R21) Apply for PAR 17 235 Funding Number: PAR 17 235 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovative Research in Cancer Nanotechnology (IRCN) (R01) Apply for PAR 17 240 Funding Number: PAR 17 240 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Mechanisms and Consequences of Sleep Disparities in the U.S. (R01) Apply for PAR 17 234 Funding Number: PAR 17 234 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fostering Research Training and Education Programs for Native American Students at NCI-designated Cancer Centers (Admin Supp) Apply for PA 17 241 Funding Number: PA 17 241 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Avenir Award Program for Research on Substance Abuse and HIV/AIDS (DP2) Apply for RFA DA 18 004 Funding Number: RFA DA 18 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R21) Apply for PA 17 243 Funding Number: PA 17 243 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R01) Apply for PA 17 239 Funding Number: PA 17 239 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Activities to Promote Research Collaborations on Immune-Related Adverse Events (APRC-irAEs) Associated with Cancer Immunotherapy (Admin Supp) Apply for PA 17 248 Funding Number: PA 17 248 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Collaborative Research Projects to Enhance Applicability of Mammalian Models for Translational Research (Collaborative R01) Apply for PAR 17 244 Funding Number: PAR 17 244 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Extracellular Vesicles and Substance Use Disorders (R21) Apply for PAR 17 242 Funding Number: PAR 17 242 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01) Apply for PAR 17 245 Funding Number: PAR 17 245 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
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