Opportunity Information: Apply for RFA DP 22 001
The grant opportunity "Real-world effectiveness of structured lifestyle interventions in preventing type 2 diabetes" (RFA DP 22 001) is a CDC cooperative agreement designed to generate strong, real-world evidence on how well structured lifestyle interventions (SLIs) delivered through the National Diabetes Prevention Program (NDPP) work over the long term. The central goal is not just to confirm whether these programs reduce diabetes risk in routine practice, but to measure their sustained impact over multiple years, determine whether they are cost-effective, and identify the real barriers that keep eligible people from enrolling, staying engaged, or completing the curriculum. In practical terms, the CDC is looking for applicants who can follow people for years, link multiple data sources at the individual level, and produce findings that reflect how NDPP-aligned programs perform across different populations and delivery formats.
The NOFO is organized into two connected components. Component A funds the actual evaluation studies. These studies must assess long-term effectiveness and cost-effectiveness among people who meet NDPP eligibility criteria and complete the NDPP curriculum, while also examining barriers to participation and adherence. A key feature is that the analysis must be able to break results down across important subgroups, including age group, sex, race/ethnicity, and socioeconomic status, so the findings can highlight inequities and practical differences in outcomes. The work must include a control or comparison group made up of individuals who also meet NDPP eligibility criteria but either never enroll in the SLI program or enroll but do not complete it. This comparison is essential for estimating the real-world impact of completing an SLI relative to not receiving or not finishing it, rather than relying only on outcomes among completers.
Component A also places heavy emphasis on data linkage and long-term follow-up. Applicants are expected to connect individual-level data from SLI program providers with electronic health records and insurance claims, then add follow-up information for at least five years. This implies the CDC wants outcomes that can be observed over time in routine health data, such as progression to type 2 diabetes, changes in cardiometabolic risk factors, healthcare utilization, and costs. The evaluation must also cover multiple delivery modalities, explicitly including in-person programs, virtual programs, and hybrid approaches that combine the two. That requirement reflects the reality that NDPP delivery has diversified and the CDC wants to understand whether long-term outcomes and adherence differ by format, and for whom.
Component B establishes a Coordinating Center role that supports and strengthens the Component A studies. The Coordinating Center is responsible for providing shared infrastructure and coordination functions that make multi-site or multi-award research more consistent and efficient. This includes support for data storage if needed, harmonizing data collection so that different projects can be compared or pooled, coordinating data analysis approaches, and providing logistical and communication support. The intent is to reduce fragmentation across separate evaluations and increase the overall quality, comparability, and usefulness of the evidence produced under the NOFO.
From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, meaning the CDC expects substantial involvement with awardees during the project rather than a hands-off grant. The opportunity sits in the health funding activity category (CFDA 93.068). Eligibility is broad and includes various levels of government (state, county, city/township), special districts, independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with and without 501(c)(3) status, and for-profit organizations (including small businesses). The award ceiling is listed as $900,000, and the expected number of awards is six. The opportunity was created on November 18, 2021, with an original application due date of January 10, 2022 (electronically submitted by 11:59 pm ET).
Overall, the NOFO is aimed at answering policy-relevant, implementation-focused questions: in everyday settings, do NDPP-aligned lifestyle programs prevent or delay type 2 diabetes over many years; are they worth the investment when costs and healthcare utilization are considered; what obstacles stop people from enrolling or completing; and how do these results vary across demographic and socioeconomic groups and across in-person versus virtual versus hybrid delivery. The required long-term, linked-data approach is meant to produce findings that are credible for decision-makers who need to scale, reimburse, and improve diabetes prevention programs in real communities.Apply for RFA DP 22 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Real-world effectiveness of structured lifestyle interventions in preventing type 2 diabetes" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068.
- This funding opportunity was created on Nov 18, 2021.
- Applicants must submit their applications by Jan 10, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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