Opportunity Information: Apply for RFA DP 22 001
The grant opportunity "Real-world effectiveness of structured lifestyle interventions in preventing type 2 diabetes" (RFA DP 22 001) is a CDC cooperative agreement designed to generate strong, real-world evidence on how well structured lifestyle interventions (SLIs) delivered through the National Diabetes Prevention Program (NDPP) work over the long term. The central goal is not just to confirm whether these programs reduce diabetes risk in routine practice, but to measure their sustained impact over multiple years, determine whether they are cost-effective, and identify the real barriers that keep eligible people from enrolling, staying engaged, or completing the curriculum. In practical terms, the CDC is looking for applicants who can follow people for years, link multiple data sources at the individual level, and produce findings that reflect how NDPP-aligned programs perform across different populations and delivery formats.
The NOFO is organized into two connected components. Component A funds the actual evaluation studies. These studies must assess long-term effectiveness and cost-effectiveness among people who meet NDPP eligibility criteria and complete the NDPP curriculum, while also examining barriers to participation and adherence. A key feature is that the analysis must be able to break results down across important subgroups, including age group, sex, race/ethnicity, and socioeconomic status, so the findings can highlight inequities and practical differences in outcomes. The work must include a control or comparison group made up of individuals who also meet NDPP eligibility criteria but either never enroll in the SLI program or enroll but do not complete it. This comparison is essential for estimating the real-world impact of completing an SLI relative to not receiving or not finishing it, rather than relying only on outcomes among completers.
Component A also places heavy emphasis on data linkage and long-term follow-up. Applicants are expected to connect individual-level data from SLI program providers with electronic health records and insurance claims, then add follow-up information for at least five years. This implies the CDC wants outcomes that can be observed over time in routine health data, such as progression to type 2 diabetes, changes in cardiometabolic risk factors, healthcare utilization, and costs. The evaluation must also cover multiple delivery modalities, explicitly including in-person programs, virtual programs, and hybrid approaches that combine the two. That requirement reflects the reality that NDPP delivery has diversified and the CDC wants to understand whether long-term outcomes and adherence differ by format, and for whom.
Component B establishes a Coordinating Center role that supports and strengthens the Component A studies. The Coordinating Center is responsible for providing shared infrastructure and coordination functions that make multi-site or multi-award research more consistent and efficient. This includes support for data storage if needed, harmonizing data collection so that different projects can be compared or pooled, coordinating data analysis approaches, and providing logistical and communication support. The intent is to reduce fragmentation across separate evaluations and increase the overall quality, comparability, and usefulness of the evidence produced under the NOFO.
From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, meaning the CDC expects substantial involvement with awardees during the project rather than a hands-off grant. The opportunity sits in the health funding activity category (CFDA 93.068). Eligibility is broad and includes various levels of government (state, county, city/township), special districts, independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with and without 501(c)(3) status, and for-profit organizations (including small businesses). The award ceiling is listed as $900,000, and the expected number of awards is six. The opportunity was created on November 18, 2021, with an original application due date of January 10, 2022 (electronically submitted by 11:59 pm ET).
Overall, the NOFO is aimed at answering policy-relevant, implementation-focused questions: in everyday settings, do NDPP-aligned lifestyle programs prevent or delay type 2 diabetes over many years; are they worth the investment when costs and healthcare utilization are considered; what obstacles stop people from enrolling or completing; and how do these results vary across demographic and socioeconomic groups and across in-person versus virtual versus hybrid delivery. The required long-term, linked-data approach is meant to produce findings that are credible for decision-makers who need to scale, reimburse, and improve diabetes prevention programs in real communities.Apply for RFA DP 22 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Real-world effectiveness of structured lifestyle interventions in preventing type 2 diabetes" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068.
- This funding opportunity was created on Nov 18, 2021.
- Applicants must submit their applications by Jan 10, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the purpose of the grant opportunity "Real-world effectiveness of structured lifestyle interventions in preventing type 2 diabetes" (RFA DP 22 001)?
This CDC cooperative agreement is intended to generate strong real-world evidence about how well structured lifestyle interventions (SLIs) delivered through the National Diabetes Prevention Program (NDPP) work over the long term. The focus is on sustained impact over multiple years, cost-effectiveness, and practical barriers that prevent eligible people from enrolling, staying engaged, or completing the program curriculum.
What kind of evidence is CDC looking for under this opportunity?
The opportunity emphasizes real-world, implementation-focused evidence rather than short-term or tightly controlled research findings. Applicants are expected to produce results that reflect routine practice across different populations and delivery formats, supported by long-term follow-up and individual-level linkage of multiple data sources.
How is this NOFO structured?
The NOFO has two connected components: Component A (Evaluation Studies) and Component B (Coordinating Center). Component A supports the evaluation studies themselves, while Component B provides shared coordination and infrastructure support to strengthen and align the Component A studies.
What is Component A?
Component A funds the evaluation studies. These studies must assess long-term effectiveness and cost-effectiveness among people who meet NDPP eligibility criteria and complete the NDPP curriculum. Component A also requires examining barriers to participation and adherence.
What is Component B?
Component B establishes a Coordinating Center that supports and strengthens Component A studies through shared infrastructure and coordination. Responsibilities include harmonizing data collection, coordinating analysis approaches, providing logistical and communication support, and offering data storage support if needed.
What outcomes are Component A studies expected to evaluate?
Studies are expected to evaluate long-term outcomes observable in routine health data over time. Examples described include progression to type 2 diabetes, changes in cardiometabolic risk factors, healthcare utilization, and costs, with follow-up information for at least five years.
How long must participants be followed for the evaluation?
The evaluation is expected to include long-term follow-up for at least five years, using linked individual-level data sources to observe outcomes over time.
What data sources are applicants expected to use?
Applicants are expected to link individual-level data from SLI program providers with electronic health records (EHRs) and insurance claims, and then add follow-up information for at least five years. The linked-data approach is central to producing credible long-term, real-world findings.
Is a control or comparison group required?
Yes. Component A requires a control or comparison group consisting of individuals who meet NDPP eligibility criteria but either never enroll in an SLI program or enroll but do not complete it. This is required to estimate the real-world impact of completing an SLI relative to not receiving or not finishing it.
Who must be included in the study population?
The study population must include people who meet NDPP eligibility criteria. The evaluation must include those who complete the NDPP curriculum, and it must also include an NDPP-eligible comparison group of non-enrollees or non-completers.
What does the NOFO mean by examining "barriers" to participation and adherence?
The NOFO calls for identifying real barriers that keep eligible individuals from enrolling in SLIs, staying engaged, or completing the NDPP curriculum. The intent is to surface practical, real-world obstacles that affect participation and completion in routine settings.
Are equity and subgroup analyses required?
Yes. The analysis must be able to break results down across key subgroups, including age group, sex, race/ethnicity, and socioeconomic status. This is meant to highlight inequities and practical differences in outcomes across different groups.
Do studies need to evaluate different delivery formats of NDPP-aligned programs?
Yes. Component A evaluations must cover multiple delivery modalities, explicitly including in-person programs, virtual programs, and hybrid approaches that combine the two. The intent is to understand whether long-term outcomes and adherence differ by delivery format, and for whom.
What is the main question CDC is trying to answer about NDPP-aligned SLIs?
The NOFO is aimed at policy-relevant questions such as whether NDPP-aligned lifestyle programs prevent or delay type 2 diabetes over many years in everyday settings, whether they are cost-effective when costs and healthcare utilization are considered, what obstacles limit enrollment and completion, and how results vary across demographic and socioeconomic groups and delivery formats.
What type of funding mechanism is this?
This is a discretionary funding opportunity using a cooperative agreement mechanism. That means CDC expects substantial involvement with awardees during the project, rather than a fully hands-off relationship.
What is the CFDA number and funding activity category?
The opportunity is in the health funding activity category and is listed under CFDA 93.068.
Who is eligible to apply?
Eligibility is broad and includes state, county, and city/township governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; and for-profit organizations including small businesses.
How many awards does CDC expect to make?
The expected number of awards is six.
What is the maximum award amount?
The award ceiling is listed as $900,000.
When was this opportunity created and when were applications due?
The opportunity was created on November 18, 2021. The original application due date was January 10, 2022, with electronic submission required by 11:59 pm Eastern Time.
Why does the NOFO emphasize linking data at the individual level?
The linked individual-level approach is intended to enable multi-year follow-up and allow outcomes to be measured in routine healthcare data. This strengthens the credibility of real-world effectiveness and cost-effectiveness estimates and supports subgroup analyses and comparisons across delivery modalities.
What is the role of the Coordinating Center in reducing fragmentation across evaluations?
The Coordinating Center is intended to improve consistency and efficiency across multi-site or multi-award work by harmonizing data collection, coordinating analytic approaches, and supporting logistics and communication. The goal is to make results more comparable (and potentially poolable) across separate evaluation efforts.
What makes this opportunity different from a typical short-term evaluation of an SLI program?
Based on the NOFO description, the defining features include long-term follow-up (at least five years), individual-level linkage of program data with EHRs and insurance claims, required comparison groups of NDPP-eligible non-enrollees or non-completers, required subgroup analyses for equity, and explicit evaluation across in-person, virtual, and hybrid delivery formats.
Browse more opportunities from the same category: Health
Next opportunity: Major Collaborative Archival Initiatives
Previous opportunity: Project to Increase Compliance with Mexican Labor Law and International Labor Standards by the Tomato and Chile Pepper Sectors in Mexico
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DP 22 001
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DP 22 001) also looked into and applied for these:
| Funding Opportunity |
|---|
| National Fetal, Infant, and Child Death Review Center Apply for HRSA 22 084 Funding Number: HRSA 22 084 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $2,449,996 |
| Rigorously Evaluating Programs and Policies to Prevent Child Sexual Abuse (CSA) Apply for RFA CE 22 003 Funding Number: RFA CE 22 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $325,000 |
| Request for Information for USAID/Southern Africa HIV Prevention and Control Among Key Populations in Lesotho Apply for RFI 674 22 KEYPOPULATIONSINLESOTHO Funding Number: RFI 674 22 KEYPOPULATIONSINLESOTHO Agency: Agency for International Development, South Africa USAID-Pretoria Category: Health Funding Amount: $25,000,000 |
| Supporting Replication (SURE) of Housing Interventions in the Ryan White HIV/AIDS Program – Implementation and Technical Assistance Provider Apply for HRSA 22 031 Funding Number: HRSA 22 031 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Supporting Replication (SURE) of Housing Interventions in the Ryan White HIV/AIDS Program – Evaluation Provider Apply for HRSA 22 032 Funding Number: HRSA 22 032 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Dental Clinician Educator Career Development Program Apply for HRSA 22 049 Funding Number: HRSA 22 049 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Family Planning Telehealth Infrastructure Enhancement and Expansion Grants Apply for PA FPH 22 002 Funding Number: PA FPH 22 002 Agency: Department of Health and Human Services, Office of the Assistant Secretary for Health Category: Health Funding Amount: $700,000 |
| Home Visiting Research and Development Platform Apply for HRSA 22 080 Funding Number: HRSA 22 080 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $1,500,000 |
| Regional Public Health Training Centers (PHTC) Program Apply for HRSA 22 055 Funding Number: HRSA 22 055 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Request for Information for USAID/Southern Africa Sustaining Epidemic Control through Integrated HIV and Health Services Program in Lesotho Apply for RFI 674 22 EPIDEMICCTLESOTHO Funding Number: RFI 674 22 EPIDEMICCTLESOTHO Agency: Agency for International Development, South Africa USAID-Pretoria Category: Health Funding Amount: $10,000,000 |
| NIOSH Education and Research Centers Apply for RFA OH 22 001 Funding Number: RFA OH 22 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $1,800,000 |
| Supporting, Mobilizing and Accelerating Research for Tuberculosis Elimination (SMART4TB) Apply for 7200AA22RFA00004 Funding Number: 7200AA22RFA00004 Agency: Agency for International Development Category: Health Funding Amount: $200,000,000 |
| High Impact Maternal, Newborn and Child Health (HI-MNCH) Activity Apply for 72048222RFA00001 Funding Number: 72048222RFA00001 Agency: Agency for International Development, Burma USAID - Rangoon Category: Health Funding Amount: $20,000,000 |
| Medicare Rural Hospital Flexibility Program- Emergency Medical Services Competing Supplement Apply for HRSA 22 063 Funding Number: HRSA 22 063 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $300,000 |
| Strengthening Healthcare Infection Prevention and Control and Improving Patient Safety in the United States Apply for CDC RFA CK22 2203 Funding Number: CDC RFA CK22 2203 Agency: Department of Health and Human Services, Centers for Disease Control - NCEZID Category: Health Funding Amount: Case Dependent |
| Nurse Education, Practice, Quality and Retention-Mobile Health Training Program (NEPQR-MHTP) Apply for HRSA 22 056 Funding Number: HRSA 22 056 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Enhancing Systems of Care for Children with Medical Complexity (Coordinating Center) Apply for HRSA 22 088 Funding Number: HRSA 22 088 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $700,000 |
| Enhancing Systems of Care for Children with Medical Complexity (Demonstration Projects) Apply for HRSA 22 098 Funding Number: HRSA 22 098 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $400,000 |
| NIOSH Centers for Agricultural Safety and Health Apply for RFA OH 22 002 Funding Number: RFA OH 22 002 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $2,200,000 |
| Children and Youth with Special Health Care Needs Research Network Apply for HRSA 22 076 Funding Number: HRSA 22 076 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DP 22 001", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.