Opportunity Information: Apply for SP 25 003
The Strategic Prevention Framework - Partnerships for Success for States (SPF-PFS-States) is a discretionary grant opportunity from the Substance Abuse and Mental Health Services Administration (SAMHSA) designed to strengthen substance use prevention efforts at the state level while also building and supporting the capacity of local prevention providers. The core idea behind the program is to help states and their community partners prevent and reduce the initiation of substance use and slow or stop the progression of substance-related problems by investing in community-based prevention services that are practical, scalable, and rooted in what works.
Programmatically, the opportunity emphasizes prevention strategies that improve conditions in communities rather than focusing only on individual behavior. Funded activities are expected to strengthen protective factors (such as supportive family and school environments, connectedness, and healthy community norms), reduce risk factors (such as community disorganization, easy access to substances, or adverse childhood experiences), build resilience, and promote overall well-being. A major theme is capacity building: states are expected to use the grant to expand and strengthen the ability of both state systems and local community prevention providers to plan, implement, and sustain effective prevention services over time.
A key priority area is ensuring prevention capacity reaches underserved communities and tribes. The grant is explicitly oriented toward expanding and strengthening the prevention workforce and infrastructure serving populations that often face higher barriers to services or experience disproportionate substance-related harms. This includes an expectation that states will support local partners in these communities with the tools, training, and implementation supports needed to deliver prevention services effectively and with cultural relevance.
Another major requirement is the use of strategies that are evidence-based, evidence-informed, or community-defined evidence-based. In practice, this means applicants should plan to select interventions and approaches supported by research where available, adapt them responsibly to local contexts when necessary, and recognize credible community-defined practices that have demonstrated effectiveness in specific populations or settings. The intention is to balance fidelity to proven models with realistic, community-grounded implementation, especially in diverse or historically underserved areas.
Eligibility is limited to states, including U.S. Territories, Pacific Jurisdictions, and the District of Columbia, reflecting the program’s focus on statewide prevention systems and state-led coordination with local providers. The funding opportunity is listed under Assistance Listing (CFDA) number 93.243 and uses the grant funding instrument. The opportunity number is SP 25 003, and the application deadline is March 18, 2025. SAMHSA expects to make around 6 awards under this announcement, with an award ceiling of $2,000,000 per award, indicating a relatively competitive program intended for large-scale, statewide prevention planning and implementation.Apply for SP 25 003
- The Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Strategic Prevention Framework – Partnerships for Success for States" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
- This funding opportunity was created on 2025-01-17.
- Applicants must submit their applications by 2025-03-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Others.
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| Creutzfeldt-Jakob Disease (CJD) Increasing Educational Support for CJD Families and the Nation Apply for CDC RFA CK 25 0144 Funding Number: CDC RFA CK 25 0144 Agency: Centers for Disease Control - NCEZID Category: Health Funding Amount: $100,000 |
| Circles of Care for American Indian/Alaska Natives (AI/AN) Apply for SM 25 016 Funding Number: SM 25 016 Agency: Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $350,000 |
| Connecting Kids to Coverage Outreach and Enrollment Cooperative Agreements (CKC) 2025 Apply for CMS 3Y3 25 001 Funding Number: CMS 3Y3 25 001 Agency: Centers for Medicare Medicaid Services Category: Health Funding Amount: $3,000,000 |
| Enhancing State No Wrong Door Systems for Efficient Access to Long-Term Services and Supports Apply for HHS 2025 ACL CIP NWGV 0029 Funding Number: HHS 2025 ACL CIP NWGV 0029 Agency: Administration for Community Living Category: Health Funding Amount: $450,000 |
| Nursing Home Staffing Campaign Apply for CMS 2V2 25 001 Funding Number: CMS 2V2 25 001 Agency: Centers for Medicare Medicaid Services Category: Health Funding Amount: $20,000,000 |
| Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) Apply for PAR 25 332 Funding Number: PAR 25 332 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed) Apply for PAR 25 374 Funding Number: PAR 25 374 Agency: National Institutes of Health Category: Health Funding Amount: $1,000,000 |
| Advancing Vision Health Equity through Multi-level Interventions and Community-Engaged Research (R01 - Clinical Trial Optional) Apply for RFA EY 25 002 Funding Number: RFA EY 25 002 Agency: National Institutes of Health Category: Health Funding Amount: $1,000,000 |
| Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R21 Clinical Trial Optional) Apply for PAR 25 331 Funding Number: PAR 25 331 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Secondary Analysis of Existing Datasets in Heart, Lung, and Blood Diseases and Sleep Disorders (R21 Clinical Trial Not Allowed) Apply for PAR 25 056 Funding Number: PAR 25 056 Agency: National Institutes of Health Category: Health Funding Amount: $75,000 |
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| Innovative Pilot Mental Health Services Research Not Involving Clinical Trials (R34 Clinical Trial Not Allowed) Apply for PAR 25 284 Funding Number: PAR 25 284 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed) Apply for PAR 25 283 Funding Number: PAR 25 283 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed) Apply for PAR 25 357 Funding Number: PAR 25 357 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required) Apply for RFA DC 25 003 Funding Number: RFA DC 25 003 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required) Apply for PAR 25 343 Funding Number: PAR 25 343 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| In Vivo High-Resolution Imaging for Inner Ear Visualization (R01 Clinical Trial optional) Apply for RFA DC 25 005 Funding Number: RFA DC 25 005 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NEI Translational Research Program for Therapeutics (R61/R33 Clinical Trial Not Allowed) Apply for PAR 25 335 Funding Number: PAR 25 335 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NEI Translational Research Program for Therapeutics (R33 Clinical Trial Not Allowed) Apply for PAR 25 363 Funding Number: PAR 25 363 Agency: National Institutes of Health Category: Health Funding Amount: $1,000,000 |
| Complement-ARIE New Approach Methodologies (NAMs) Data Hub and Coordinating Center (U24 Clinical Trial Optional) Apply for RFA RM 24 013 Funding Number: RFA RM 24 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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